Physical and Chemical Properties of Lactose
The primary carbohydrate of the milk of most mammals is lactose (4-O-β-D-galactopyranosyl-D-glucopyranose), commonly called milk sugar, and milk is the sole source of lactose for all practical purposes. However, the California sea lion and other Pacific pinnipeds have no lactose in their milks (Pilson and Kelly, 1962; Pilson, 1965; Johnson et al. 1974; Stewart et al., 1983). Milks of monotremes, such as the echidna and platypus, contain less than 0.1% lactose (Morrissey, 1985), while human milk contains one of the highest levels of lactose at about 7% (Renner, 1983). Bovine milks average 4.8% anhydrous lactose, amounting to about 50% of the total solids of skimmed milk.
Mention of brand or firm names does not constitute an endorsement by the US Department of Agriculture over others of a similar nature not mentioned.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Subscribe and save
Springer+ Basic
€32.70 /Month
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime
Buy Now
Price includes VAT (France)
eBook EUR 67.40 Price includes VAT (France)
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Similar content being viewed by others
Lactose
Chapter © 2015
Lactose: Occurrence, Properties, Reactions, and Significance
Chapter © 2022
Chemistry of Milk Constituents
Chapter © 2017
References
- American Academy of Pediatrics, Committee on Nutrition (1990) Practical significance of lactose intolerance in children: supplement. Pediatrics86, 643–4. Google Scholar
- Andrews, G.R. (1984) Distinguishing pasteurized, UHT and sterilized milks by their lactulose content. J. Soc. Dairy Technol., 37, 92–5. ArticleCASGoogle Scholar
- Andrews, G. (1989) Lactulose in heated milk, in Monograph on Heat-Induced Changes in Milk, ed P.F. Fox, Bulletin 238, International Dairy Federation, Brussels, pp. 46–52. Google Scholar
- Anonymous (1990) Research plan gives whey to clear highways. Dayton Daily News, Friday, August 24, Dayton, OH, p. 1-D. Google Scholar
- Anonymous (1995) Food Chemical News, Vol. 37(3): March 13, CRC Press, Inc., Washington, DC, p. 15. Google Scholar
- Barry, J.M. and Rowland, J.J. (1953) Variations in the ionic and lactose concentrations in milk. Biochem. J., 54, 575–8. CASGoogle Scholar
- Berg, H.E. and van Boekel, M.A.J.S. (1994) Degradation of lactose during heating of milk. 1. Reaction pathways. Neth. Milk Dairy J., 48, 157–75. CASGoogle Scholar
- Berlin, E., Anderson, B.A., and Pallansch, M.J. (1968a) Water vapor sorption properties of various dried milks and wheys. J. Dairy Sci., 51, 1339–44. ArticleCASGoogle Scholar
- Berlin, E., Anderson, B.A. and Pallansch, M.J. (1968b) Comparison of water vapor sorption by milk powder components. J. Dairy Sci., 51, 1912–15. ArticleGoogle Scholar
- Berlin, E., Kliman, P.G., Anderson, B.A. and Pallansch, M.J. (1973) Water binding in whey concentrates. J. Dairy Sci., 56, 984–7. ArticleCASGoogle Scholar
- Berliner, L.J. and Johnson, J.D. (1988) a-Lactalbumin and calmodulin, in Calcium Binding Proteins, Vol. II, Biological Functions, (M.P. Thompson ed.) CRC Press, Boca Raton, FL, pp. 79–116. Google Scholar
- Berliner, L.J., Andree, P.J. and Kaptein, R. (1978) ESR, NMR and CIDNP studies of cation binding to a-lactalbumin. Proc. 7th Int. Conf. Magnetic Resonance Biological Systems, Nara, Japan, p. 115. Google Scholar
- Berliner, L.J., Davis, M.E., Ebner, K.E., et al. (1984) The lactose synthase acceptor site: a structural map derived from acceptor studies. Mol. Cell Biochem., 62, 37–42. ArticleCASGoogle Scholar
- Berliner, L.J., Koga, K., Nishikawa, H. and Scheffler, J.E. (1987) High-resolution proton and laser photochemically induced dynamic nuclear polarization NMR studies of cation binding to bovine a-lactalbumin. Biochemistry, 26, 5769–79. ArticleCASGoogle Scholar
- Blankers, I. (1995) Properties and applications of lactitol. Food Technol., 49, 66–8. CASGoogle Scholar
- Brew, K., Shaper, J.H., Olsen, K.W., et al. (1975) Cross-linking of the components of lactose synthetase with dimethylpimelimidate. J. Biol. Chem., 250, 1434–44. CASGoogle Scholar
- Brinkman, G.E. (1976) New ideas for the utilization of lactose — principles of lactose manufacture. J. Soc. Dairy Technol., 29, 101–7. ArticleCASGoogle Scholar
- Buma, T.J. and Wiegers, G.A. (1967) X-ray powder patterns of lactose and unit cell dimensions of 0-lactose. Neth. Milk Dairy J., 21, 208–13. CASGoogle Scholar
- Burton, H. (1984) Reviews of the progress of dairy science: the bacteriological, chemical, biochemical and physical changes that occur in milk at temperatures of 100–150°C. J. Dairy Res., 51, 341–63. ArticleCASGoogle Scholar
- Bushill, H., Wright, W.B., Fuller, C.H.F. and Bell, A.V. (1969) The crystallization of lactose with particular reference to its occurrence in milk powder, in Proc. First Int. Congr. Food Sci. Technol. Vol. 1. Chemical and Physical Aspects of Food, (J.M. Leitch ed.) London, September 18–21, 1962, Gordon and Breach Science Publishers, New York, pp. 237–45. Google Scholar
- Carie, M. (1994) Concentrated and Dried Dairy Products, VCH Publishers, Inc., New York, pp. 1–249. Google Scholar
- Carie, M. and Kalab, M. (1987) Effects of drying techniques on milk powders (sic) quality and microstructure: a review. Food Microstructure, 6, 171–80. Google Scholar
- Cerbulis, J., Pfeffer, P.E. and Farrell, H.M., Jr. (1978) Reaction of lactose with urea. Carbohydr. Res., 65, 311–13. ArticleCASGoogle Scholar
- Chiu, C.P. and Kosikowski, F.V. (1985) Hydrolyzed lactose syrup from concentrated sweet whey permeates. J. Dairy Sci., 68, 16–22. ArticleCASGoogle Scholar
- Clamp, J.R., Hough, L., Hickson, J.L. and Whistler, R.L. (1961) Lactose, in Advances in Carbohydrate Chemistry, Vol 16, ( M.L. Wolfram and R.S. Tyson eds.) Academic Press, New York, pp. 159–206. Google Scholar
- Code of Federal Regulations (1994) 172.720, Calcium lactobionate, in Title 21: Food and Drugs,Food and Drug Administration, 1 April, pp. 63–4. Google Scholar
- Coughlin, J.R. and Nickerson, T.A. (1975) Acid-catalyzed hydrolysis of lactose in whey and aqueous systems. J. Dairy Sci., 58, 169–74. ArticleCASGoogle Scholar
- de Boer, R. and Robbertsen, T. (1981) A purified hydrolyzed lactose syrup made from ultrafiltration permeate. Neth. Milk Dairy J., 35, 95–111. Google Scholar
- de Vrese, M. (1993) Physiological and metabolic effects of consuming hydrolyzed lactose products, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 62–4. Google Scholar
- Delmont, J. (1983) Milk Intolerances and Rejections, S. Karger, Basel, pp. 1–169. Google Scholar
- Doner, L.W. and Hicks, K.B. (1982) Lactose and the sugars of honey and maple: reactions, properties and analysis, in Food Carbohydrates, ( D.R. Lineback and G.E. Inglett eds.) AVI Publishing Co., Westport, CT, pp. 74–112. Google Scholar
- Domovs, K.B. and Freund, E.H. (1960) Methanol-soluble complexes of lactose and of other carbohydrates. J. Dairy Sci., 42, 1216–23. ArticleGoogle Scholar
- Ebner, K.E. and Schanbacher, F.L. (1974) Biochemistry of lactose and related carbohydrates, in Lactation: A Comprehensive Treatise, Vol. II, ( B.L. Larson and V.R. Smith eds.) Academic Press, New York, pp. 77–113. Google Scholar
- Erbersdobler, H.F. (1986) Twenty years of furosine — better knowledge about the biological significance of Maillard reaction in food and nutrition, in Amino-Carbonyl Reactions in Food and Biological Systems, ( M. Fujimaki, M. Namiki and H. Kato eds.) Elsevier, Amsterdam, pp. 481–91. Google Scholar
- Erbersdobler, H.F. and Dehn-Müller, B. (1989) Formation of early Maillard products during UHT treatment of milk, in Heat-induced Changes in Milk, (P.F. Fox ed.) Bulletin 238, International Dairy Federation, Brussels, pp. 62–7. Google Scholar
- Fuertes, P. and Fleche, G. (1991) Process for oxidation of di-, tri-, oligo-andpolysaccharides into polyhydroxycarboxylic acids, the catalyst used and the products so obtained. Eur. Patent232, 202. Google Scholar
- Geilman, W.G. (1993) Preparation and properties of syrups made by the hydrolysis of lactose, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 33–7. Google Scholar
- Grenby, T.H. (1989) Latest state of research on lactitol and dental caries. Int. Dental J., 39, 25–32. CASGoogle Scholar
- Guy, E.J. (1982) Stabilization of frozen goat milk concentrates by enzymatic lactose hydrolysis. J. Food Sci., 47, 423–8. ArticleCASGoogle Scholar
- Hall, C.W. and Hedrick, T.I. (1971) Drying of Milk and Milk Products, 2nd edn, AVI Publishing Co., Westport, CT, pp. 1–338. Google Scholar
- Hanrahan, F.P. and Webb, B.H. (1961a) Spray drying cottage cheese whey. J. Dairy Sci., 44, 1171 (abstract). Google Scholar
- Hanrahan, F.P. and Webb, B.H. (1961b) U.S. Department of Agriculture develops foam-spray drying. Food Eng., 33 (8), 37–8. Google Scholar
- Hargrove, R.E., McDonough, F.E., LaCroix, D.E. and Alford, J.A. (1976) Production and properties of deproteinized whey powders. J. Dairy Sci., 59, 25–33. ArticleGoogle Scholar
- Harju, M. (1993) Production and properties of lactulose, lactitol and lactobionic acid, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 27–30. Google Scholar
- Harju, M., Vesanen, K., Perttila, M. and Jalkanen, M. (1990) A new method to improve the yield in the lactose manufacture. Brief Comm. and Abstr. Posters 23rd Int. Dairy Congr., Vol. II., p. 427 (abstract). Google Scholar
- Hendriks, H.E.J., Kuster, B.F.M. and Martin, G.B. (1990) The effect of bismuth on the selective oxidation of lactose on supported palladium catalysts. Carbohydr. Res., 204, 121–9. ArticleCASGoogle Scholar
- Herrington, B.L. (1948) Milk and Milk Processing, McGraw Hill Book Co., New York, p. 84. Google Scholar
- Hicks, K.B. and Parrish, F.W. (1980) A new method for preparation of lactulose from lactose. Carbohydr. Res., 82, 393–7. ArticleCASGoogle Scholar
- Hicks, K.B., Raupp, D.L. and Smith, P.W. (1984) Preparation of purification of lactulose from sweet cheese whey ultrafiltrate. J. Agric. Food Chem., 32, 28892. ArticleGoogle Scholar
- Hoagland, P.D., Pfeffer, P.E. and Valentine, K.M. (1979) Reductive amination of lactose: unusual 13C-NMR spectroscopic properties of N-alkyl-(1-deoxylactitol1-yl) amines. Carbohydr. Res., 74, 135–43. ArticleCASGoogle Scholar
- Hobman, P.G. (1984) Review of processes and products for utilization of lactose in deproteinized milk serum. J. Dairy Sci., 67, 2630–53. ArticleCASGoogle Scholar
- Hoffmann, K. (1975) Behandlung von gesunden Salmonellen-Ausscheidern mit Lactulose (ß-Galaktosido-Fructose). Dtsch. Med. Wochenschr., 100, 1429–31. ArticleCASGoogle Scholar
- Holsinger, V.H. (1978) Application of lactose modified milk and whey. Food Technol., 32, 35–6, 38, 40. Google Scholar
- Holsinger, V.H. (1987) Lactose, in Fundamentals of Dairy Chemistry, 3rd edn, ( N.P. Wong, R. Jenness, M. Keeney and E.H. Marth eds.) Van Nostrand Reinhold Co., New York, pp. 279–342. Google Scholar
- Holsinger, V.H. and Kligerman, A.E. (1991) Applications of lactase in dairy foods and other foods containing lactose. Food Technol., 45(1), 92, 94–5. Google Scholar
- Horton, B.S. (1987) Anaerobic fermentation and ultra-osmosis, in Trends in Whey Utilization, Bulletin 212, International Dairy Federation, Brussels, pp. 77–83. Google Scholar
- Hramtsov, A.G., Rokhmistrov, V.V., Evdokimov, I.A., Kostina, V.V., Abdulina, E.R. and Pavlov, V.A. (1990) Milk sugar making by membrane technology. Brief Comm. and Abstr. Posters 23rd Int. Dairy Congr., Vol. II. Montreal, p. 393 (abstract). Google Scholar
- Hunziker, O.F. (1946) Condensed Milk and Milk Products, 6th edn, Hunziker, La Grange, IL, pp. 133–90. Google Scholar
- Hustad, G.O., Richardson, T. and Amundson, C.H. (1970) Polyurethane foams from dried whey. J. Dairy Sci., 53, 18–24. ArticleCASGoogle Scholar
- IDF (1991) Heat treated milk — determination of lactulose content (HPLC and GC methods). International Standard No. 147:1991, International Dairy Federation, Brussels. Google Scholar
- IDF (1993) Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 3–71. Google Scholar
- Isaacson, Y., Salem, O., Shepherd, R.E. and, van Thiel, D.H. (1989) Lactobionic acid as an iron chelator: a rationale for its effectiveness as an organ preservant. Life Sci., 45, 2373–80. CASGoogle Scholar
- Jelen, P. (1993) Lactose hydrolysis using sonicated dairy cultures, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 54–6. Google Scholar
- Jenness, R. and Sloan, R.E. (1970) The composition of milks of various species: a review. Dairy Sci. Abstr., 32, 599–607. Google Scholar
- Jenness, R., Regehr, E.A. and Sloan, R.E. (1964) Comparative biochemical studies of milks. II. Dialyzable carbohydrates. Comp. Biochem. Physiol., 13, 339–53. ArticleCASGoogle Scholar
- Johnson, J.D., Kretchmer, N. and Simoons, F.J. (1974) Lactose malabsorption: its biology and history, in Advances in Pediatrics, Vol. 21, ( I. Schulman ed.) Yearbook Publishers, Chicago, pp. 197–237. Google Scholar
- Jones, E.A. (1978) Lactose biosynthesis, in Lactation: A Comprehensive Treatise, Vol. IV, ( B.L. Larson and V.R. Smith eds.) Academic Press, New York, pp. 371–85. Google Scholar
- Keller, A.K. (1990) Permeate utilization, in Proceedings, Dairy Products Technical Conference, American Dairy Products Institute, Chicago, pp. 101–7. Google Scholar
- Kitahata, S., Fujita, K., Takagi, Y., et al. (1992) Galactosylation at side chains of branched cyclodextrins by various ß-galactosidases. Biosci. Biotechnol. Biochem., 56, 242–5. ArticleCASGoogle Scholar
- Kozempel, M. and Kurantz, M. (1994a) The isomerization kinetics of lactose to lactulose in the presence of borate. J. Chem. Tech. Biotechnol., 59, 25–9. ArticleCASGoogle Scholar
- Kozempel, M. and Kurantz, M. (1994b) A continuous reactor system for production of lactulose. J. Chem. Tech. Biotechnol., 59, 265–9. ArticleCASGoogle Scholar
- Kuhn, R. and Low, I.L. (1949) The occurrence of lactose in the plant kingdom. Chem. Ber., 82, 479–81. ArticleCASGoogle Scholar
- Kumar, S., Clarke, A.R., Hooper, M.L., et al. (1994) Milk composition and lactation of 0-casein-deficient mice. Proc. Natl. Acad. Sci. USA, 91, 6138–42. ArticleCASGoogle Scholar
- Leviton, A. and Leighton, A. (1938) Separation of lactose and soluble proteins of whey by alcohol extraction. Ind. Eng. Chem., 30, 1305–11. ArticleCASGoogle Scholar
- Lin, A.Y. and Nickerson, T.A. (1977) Acid hydrolysis of lactose in whey versus aqueous solutions. J. Dairy Sci., 60, 34–9. ArticleCASGoogle Scholar
- Linzell, J.L. and Peaker, M. (1971) Mechanism of milk secretion. Physiol. Rev., 51, 564–97. CASGoogle Scholar
- Little, C.L. (1991) Freeze dried sweetened condensed milk crystals and process of making. US Patent5, 024, 848. Google Scholar
- MacBean, R.D. (1979) Lactose crystallization and lactose hydrolysis. N.Z. J. Dairy Sci. Technol., 14, 113–19, 128–30. Google Scholar
- Mahoney, R.R. (1985) Modification of lactose and lactose-containing dairy products with ß-galactosidase, in Developments in Dairy Chemistry-3—Lactose and Minor Constituents, ( P.F. Fox ed.) Elsevier Applied Science Publishers, London, pp. 69–109. ChapterGoogle Scholar
- Mepham, T.B. (ed.) (1987) Physiology of Lactation, Open University Press, Milton Keynes, pp. 30–50. Google Scholar
- Miller, G.D., Jarvis, J.K. and McBean, L.D. (1994) Handbook of Dairy Foods and Nutrition, CRC Press, Boca Raton, FL, pp. 1–260. Google Scholar
- Mitchell, I.R. (1991) Uses for lactose-hydrolyzed dairy products. CSIRO Food Res. Q., 51 (1 2), 107–13. Google Scholar
- Modler, H.W. (1993) Summary of discussions, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 3–6. Google Scholar
- Modler, H.W., Gelda, A., Yaguchi, M. and Gelda, S. (1993) Production of fluid milk with a high degree of lactose hydrolysis, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 57–61. Google Scholar
- Morrissey, P.A. (1985) Lactose: chemical and physicochemical properties, in Developments in Dairy Chemistry -3, ( P.F. Fox ed.) Elsevier Applied Science Publishers, London, pp. 1–34. ChapterGoogle Scholar
- Mulherin, B, Muller, T., Delaney, R.A.M. and Harper, W.J. (1979) Acid catalyzed hydrolysis of lactose with cation exchange resins. N.Z. J. Dairy Sci. Technol., 14, 127–30. CASGoogle Scholar
- Mullin, J.W. (1961) Crystallization, Butterworths, London, pp. 21–43. Google Scholar
- Murakami, K. and Berliner, L.J. (1983) A distinct zinc binding site in the a-lactal-bumins regulates calcium binding. Is there a physiological role for this control? Biochemistry, 22, 3370–4. ArticleCASGoogle Scholar
- Nickerson, T.A. (1962) Lactose crystallization in ice cream. IV. Factors responsible for reduced incidence of sandiness. J. Dairy Sci., 45, 354–9. ArticleCASGoogle Scholar
- Nickerson, T.A. (1974) Lactose, in Fundamentals of Dairy Chemistry, 2nd edn, (B.H. Webb, A.H. Johnson and J.A. Alford eds.) AVI Publishing Co., Westport, CT, pp. 273–324. Google Scholar
- O’Brien, D.J., Panzer, C.C. and Eisele, W.P. (1990) Biological production of acrylic acid from cheese whey by resting cells of Clostridium propionicum. Biotechnol. Prog., 6, 237–42. ArticleGoogle Scholar
- O’Brien, J.M. and Morrissey, P.A. (1989) The Maillard reaction in milk products, in Monograph on Heat-Induced Changes in Milk, (P.F. Fox ed.) Bulletin 238, International Dairy Federation, Brussels, pp. 53–61. Google Scholar
- Olano, A. and Martinez-Castro, I. (1989) Modification and interactions of lactose, in Monograph on Heat-Induced Changes in Milk, (P.F. Fox ed.) Bulletin 238, International Dairy Federation, Brussels, pp. 35–44. Google Scholar
- Olano, A., Bernhard, R.A. and Nickerson, T.A. (1977) Alteration in the ratio of a-to 13-lactose co-crystallized from organic solvents. J. Food Sci., 42, 1066–8, 1083. ArticleGoogle Scholar
- Onwulata, C.I., Smith, P.W., Craig, J.C., Jr. and Holsinger, V.H. (1994) Physical properties of encapsulated spray dried milkfat. J. Food Sci., 59, 316–20. ArticleCASGoogle Scholar
- Paige, D.M. and Bayless, T.M. (eds.) (1981) Lactose Digestion: Clinical and Nutritional Implications, Johns Hopkins University Press, Baltimore, pp. 3–280. Google Scholar
- Pallansch, M.J. (1973) New methods for drying acid whey, in Proc. Whey Products Conf., 1972, ERRL. Publ. No. 3779, USDA, ARS, Eastern Regional Research Center, Philadelphia, pp. 100–10. Google Scholar
- Palumbo, M.S., Smith, P.W., Strange, E.D., et al. (1995) Stability of (3-galactosidase from Aspergillus oryzae and Kluyveromyces lactis in dry milk powders. J. Food Sci., 60, 117–19. ArticleGoogle Scholar
- Patil, D.H., Westaby, D., Mahida, Y.R., et al. (1987) Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy. Gut, 28, 255–9. ArticleCASGoogle Scholar
- Patton, S. (1955) Browning and associated changes in milk and its products: a review. J. Dairy Sci., 38, 457–78. ArticleCASGoogle Scholar
- Peaker, M. (1980) Influence of diet on the yields and contents of lactose and minerals in milk, in Factors Affecting the Yields and Contents of Milk Constituents of Commercial Importance, (J.H. Moore and A.F. Rook eds.) Bulletin 125, International Dairy Federation, Brussels, pp. 159–63. Google Scholar
- Peebles, D.D. (1956) The development of instant milk. Food Technol., 10, 64–5. P.effer, P.E., Valentine, K.M. and Parrish, F.W. (1979) Deuterium-induced differential isotope shift 13C NMR. 1. Resonance reassignments of mono-and disaccharides. J. Am. Chem. Soc., 1001, 1265–74. Google Scholar
- Pfeffer, P.E., Hicks, K.B. and Earl, W.L. (1983) Solid state structures of ketodisaccharides as probed by 13C cross-polarization “magic angle” spinning NMR spectroscopy. Carbohydrate Res., 11, 181–94. ArticleGoogle Scholar
- Pilson, M.E.Q. (1965) Absence of lactose from the milk of the Otarioidea, a super-family of marine animals. Am. Zool., 5, 220–1. Google Scholar
- Pilson, M.E.Q. and Kelly, A.L. (1962) Composition of the milk from Zalophus californianus, the California sea lion. Science, 135, 104–5. ArticleCASGoogle Scholar
- Qadeer, M.A., Baig, M.A. and Yunus, O. (1974) Biosynthesis of calcium lactobionate by Pseudomonas species in shake flasks. Pakistan J. Biochem., VII(1), 24–8. Google Scholar
- Ramsdell, G.A. and Webb, B.H. (1945) The acid hydrolysis of lactose and the preparation of hydrolyzed lactose syrup. J. Dairy Sci., 28, 677–86. ArticleCASGoogle Scholar
- Reimerdes, E.H. (ed.) (1990) Lactose as a Food Ingredient, Association of Lactose Manufacturers, Expoconsult Publishers, Maarssen, The Netherlands, pp. 4–55. Google Scholar
- Reithel, F.J. and Venkataraman, R. (1956) Lactose in the Sapotaceae. Science, 123, 1083. ArticleCASGoogle Scholar
- Renner, E. (1983) Milk and Dairy Products in Human Nutrition, V-*GmbH., Volkswirtschaftlicher Verlag, Munich, pp. 1–450. Google Scholar
- Richardson, R.H. and Brew, K. (1980) Lactose synthase: an investigation of the interaction site of a-lactalbumin for galactosyl transferase by differential kinetic labeling. J. Biol. Chem., 255, 3377–85. CASGoogle Scholar
- Roelfsema, W.A. and Kuster, B.F.M. (1988) Prospects in the chemical derivatisation of lactose. Neth. Milk Dairy J., 42, 469–83. CASGoogle Scholar
- Saltmarch, R., Vagnini-Ferrari, M.A. and Labuza, T.P. (1981) Theoretical basis and application of kinetics to browning in spray dried food systems. Prog. Food Nutr. Sci., 5, 331–44. Google Scholar
- Schaafsma, G. (1990) Physiological aspects of lactose in human nutrition, in Lactose as a Food Ingredient, ( E.H. Reimerdes ed.) Association of Lactose Manufacturers, Expoconsult Publishers, Maarssen, The Netherlands, pp. 13–19. Google Scholar
- Scholnick, F. and Pfeffer, P.E. (1980) Iron chelating capacity of gluconamides and lactobionamides. J. Dairy Sci., 63, 471–3. ArticleCASGoogle Scholar
- Schwartz, R.D. (1987) Biopolymers from whey, in Trends in Whey Utilization, Bulletin 212, International Dairy Federation, Brussels, pp. 56–61. Google Scholar
- Sharp, P.F. and Doob, H. Jr. (1941) Quantitative determination of a-and (3-lactose in dried milk and dried whey. J. Dairy Sci., 24, 589–601. ArticleCASGoogle Scholar
- Short, J.L. (1978) Prospects for the utilization of deproteinated whey in New Zealand — a review. N.Z. J. Dairy Sci, Technol., 13, 181–94. CASGoogle Scholar
- Singh, R.K., Shah, B.B., Nielsen, S.S. and Chambers, J.V. (1991) a-Lactose monohydrate from ultrafiltered whey permeate in one-step crystallization using ethanol-water mixtures. J. Food Sci.,56 777–81, 788. Google Scholar
- Smart, J.B. (1993) Transferase reactions of 13-galactosidases — new product opportunities, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 16–22. Google Scholar
- Solvay Deutschland GmBh (1994) Lactobionic acid and derivatives, Forschung und Entwicklung, Technical Information Brochure, Hannover, Germany. Google Scholar
- Somkuti, G.A. and Steinberg, D.H. (1990) Lactose hydrolyis by lactose transport system defective (lacS) Streptococcus thermophilus. Biotechnol. Appl. Biochem., 12, 351–6. CASGoogle Scholar
- Somkuti, G.A. and Steinberg, D.H. (1991) Lactose hydrolysis by mutant Streptococcus thermophilus. US Patent5, 071, 763. Google Scholar
- Somkuti, G.A. and Steinberg, D.H. (1993) Lactose hydrolysis by mutant Streptococcus thermophilus. US Patent5, 198, 351. Google Scholar
- Somkuti, G.A. and Steinberg, D.H. (1994) Permeabilization of Streptococcus thermophilus and the expression of beta-galactosidase. Enzyme Microb. Technol., 16, 357–6. ArticleGoogle Scholar
- Stewart, R.E.A., Webb, B.E., Lavinge, D.M. and Fletcher, F. (1983) Determining lactose content of harp seal milk. Can. J. Zool., 61, 1094–100. ArticleCASGoogle Scholar
- Stinnakre, M.G., Vilotte, J.L., Soulier, S. and Mercier, J.C. (1994) Creation and phenotypic analysis of a-lactalbumin-deficient mice. Proc. Natl. Acad. Sci. USA, 91, 6544–8. ArticleCASGoogle Scholar
- Sumimoto, R. and Kamada, N. (1990) Lactobionate as the most important component in UW solution for liver preservation. Transplant. Proc., 22, 2198–9. CASGoogle Scholar
- Tamsma, A., Kontson, A., Sutton, C. and Pallansch, M.J. (1972) Production of non-hygroscopic foam-spray dried cottage cheese whey. J. Dairy Sci., 55, 667. Google Scholar
- Tamura, Y., Mizota, T., Shimamura, S. and Tornita, M. (1993) Lactulose and its application to the food and pharmaceutical industries, in Lactose Hydrolysis, Bulletin 289, International Dairy Federation, Brussels, pp. 43–53. Google Scholar
- Thelwall, L.A.W. (1985) Developments in the chemistry and chemical modification of lactose, in Developments in Dairy Chemistry —3— Lactose and Minor Constituents, ( P.E. Fox ed.) Elsevier Applied Science Publishers, London, pp. 35–67. ChapterGoogle Scholar
- Thompson, M.P., Farrell, H.M., Mohanam, S., et al. (1992) Identification of human milk a-lactalbumin as a cell growth inhibitor. Protoplasma, 167, 134–44. ArticleCASGoogle Scholar
- Toba, T., Yokota, A. and Adachi, S. (1985) Oligosaccharide structures formed during the hydrolysis of lactose by Aspergillus oryzae ß-galactosidase. Food Chem., 16, 147–62. ArticleCASGoogle Scholar
- Troy, H.C. and Sharp, P.F. (1930) Alpha and beta lactose in some milk products. J. Dairy Sci., 13, 140–57. ArticleCASGoogle Scholar
- Trucco, R.E., Verdier, P. and Rega, A. (1954) New carbohydrate compounds from cow milk. Biochim. Biophys. Acta, 15, 852–3. ArticleGoogle Scholar
- US Food and Drug Administration (1993) PURAC biochim b.v.; filing of petition for affirmation of GRAS status (lactitol). Fed. Reg., 58, 47746. Google Scholar
- van Velthuijsen, J.A. (1979) Food additives derived from lactose: lactitol and lactitol palmitate. J. Agric. Food Chem., 27, 680–6. ArticleGoogle Scholar
- Walstra, P. and Jenness, R. (1984) Dairy Chemistry and Physics, John Wiley and Sons, New York, pp. 27–41. Google Scholar
- Webb, B.H. (1970) Condensed products, in Byproducts from Milk, 2nd edn, (B.H. Webb and E.O. Whittier eds.) AVI Publishing Co., Westport, CT, pp. 83–123. Google Scholar
- Wessinger, E.W., O’Brien, D.J. and Kurantz, M.J. (1990) Identification of fungi for sweet whey permeate utilization and eicosapentaenoic acid production. J. Industrial Microbiol., 6, 191–7. ArticleCASGoogle Scholar
- Wheadon, M. Goulding, A., Barbezat, G.O. and Campbell, A.J. (1991) Lactose malabsorption and calcium intake as a risk factor for osteoporosis in elderly New Zealand women. N.Z. Med. J.,104(921) 417–19. Google Scholar
- Whittier, E.O. (1944) Lactose and its utilization: a review. J. Dairy Sci., 27, 50537. ArticleGoogle Scholar
- Woychik, J.H. (1982) Whey and lactose, in CRC Handbook of Processing and Utilization in Agriculture. Vol. I. Animal Products, ( I.A. Wolff ed.) CRC Press, Boca Raton, FL, pp. 431–43. Google Scholar
- Wright, D.G. and Rand, A.G. (1973) Direct enzymatic conversion of lactose to acid: lactose dehydrogenase. J. Food Sci., 38, 1132–5. ArticleGoogle Scholar
- Yanahira, S., Suguri, T., Yakabe, T., et al. (1992) Formation of oligosaccharides from lactitol by Aspergillus oryzae ß-D-galactosidase. Carbohydr. Res., 232, 151–9. ArticleCASGoogle Scholar
- Young, S.L., Sarda, X. and Rosenberg, M. (1993) Microencapsulating properties of whey protein. 1. Microencapsulation of anhydrous milkfat. J. Dairy Sci., 76, 2868–77. ArticleCASGoogle Scholar
- Zadow, J.G. (1984) Lactose: properties and uses. J. Dairy Sci., 67, 2654–79. ArticleCASGoogle Scholar
- Zadow, J.G. (1986) Utilisation of milk components: whey, in Modern Dairy Technology, Advances in Milk Processing, Vol1, ( R.K. Robinson ed.) Elsevier Google Scholar
- Applied Science Publishers, London, pp. 273–316. Google Scholar
- Zadow, J.G. (1991) Lactose utilization, in CSIRO Food Research Quarterly, 51(1 2 ), 99–106. Google Scholar
- Ziegler, E.E. and Foman, S.J. (1983) Lactose enhances mineral absorption in infancy. J. Pediatr. Gastroenterol. Nutr., 2, 288–94. CASGoogle Scholar
- V. H. Holsinger